普通话在线游戏学习系统的研究与应用

针对希望进一步掌握普通话口语学习的外国学习者,该研究提出了一种普通话游戏学习系统.系统的学习模式结合了计算机技术和语言学研究成果,打破了传统的教学模式的限制,对学习者进行实时评测,提供学习报告与口语学习的最终评定结果.结果表明,该系统能够较为有效地辅助外国学习者的普通话口语学习.     

Synergetic effect of multiple phases on hydrogen desorption kinetics and cycle durability in ball milled MgH2–PrF3–Al–Ni composite

A new MgH₂–PrF₃–Al–Ni composite was prepared by ball milling under hydrogen atmosphere. After initial dehydrogenation and rehydrogenation, Pr₃Al₁₁, MgF₂, PrH₃ and Mg₂NiH₄ nanoparticles formed accompanying the main phase MgH₂. The hydrogen absorption-desorption properties were measured by using a Sieverts-type apparatus. The results showed that the MgH₂–PrF₃–Al–Ni composite improved cycle stability and enhanced hydrogen desorption kinetics. The improvement of hydrogen absorption-desorption properties is ascribed to the synergetic effect of the in situ formed Pr₃Al₁₁, MgF₂, PrH₃ and Mg₂NiH₄ nanoparticles. This work provides an important inspiration for the improvement of hydrogen storage properties in Mg-based materials.     

Improved hemimorphite flotation using xanthate as a collector with S(Ⅱ) and Pb(Ⅱ) activation

The flotation of hemimorphite using the S(Ⅱ)–Pb(Ⅱ)–xanthate process,which includes sulfidization with sodium sulfide,activation by lead cations,and subsequent flotation with xanthate,was investigated.The flotation results indicated that hemimorphite floats when the S(Ⅱ)–Pb(Ⅱ)–xanthate process is used; a maximum recovery of approximately 90% was obtained.Zeta-potential,contact-angle,scanning electron microscopy–energy-dispersive spectrometry(SEM–EDS),and diffuse-reflectance infrared Fourier transform spectroscopy(DRIFTS) measurements were used to characterize the activation products on the hemimorphite surface and their subsequent interaction with sodium butyl xanthate(SBX).The results showed that a Zn S coating formed on the hemimorphite surface after the sample was conditioned in an Na2 S solution.However,the formation of a Zn S coating on the hemimorphite surface did not improve hemimorphite flotation.With the subsequent addition of lead cations,Pb S species formed on the mineral surface.The formation of the Pb S species on the surface of hemimorphite significantly increased the adsorption capacity of SBX,forming lead xanthate(referred to as chemical adsorption) and leading to a substantial improvement in hemimorphite flotation.Our results indicate that the addition of lead cations is a critical step in the successful flotation of hemimorphite using the sulfidization–lead ion activation–xanthate process.     

颈型颈椎病功能锻炼的研究概述

近年来,颈型颈椎病的发病率不断增高,对人们的工作、生活造成严重影响。研究表明,功能锻炼对颈型颈椎病的康复有重要作用,功能锻炼的方法分为传统中医气功锻炼法、肌力锻炼和保健操3类,这些方法实用、有效、方便,在颈型颈椎病的治疗中可以综合运用这些方法,从而在更短的时间里收到比以往更好的疗效。     

The Convergence of Least-Squares Progressive Iterative Approximation for Singular Least-Squares Fitting System

Data fitting is an extensively employed modeling tool in geometric design. With the advent of the big data era, the data sets to be fitted are made larger and larger, leading to more and more leastsquares fitting systems with singular coefficient matrices. LSPIA (least-squares progressive iterative approximation) is an efficient iterative method for the least-squares fitting. However, the convergence of LSPIA for the singular least-squares fitting systems remains as an open problem. In this paper, the authors showed that LSPIA for the singular least-squares fitting systems is convergent. Moreover, in a special case, LSPIA converges to the Moore-Penrose (M-P) pseudo-inverse solution to the leastsquares fitting result of the data set. This property makes LSPIA, an iterative method with clear geometric meanings, robust in geometric modeling applications. In addition, the authors discussed some implementation detail of LSPIA, and presented an example to validate the convergence of LSPIA for the singular least-squares fitting systems.     

油缸液压特性对喷浆台车机械臂结构的影响

首先利用压力传感器测试在实际施工过程中的臂架系统的液压特性曲线,以此作为机械臂有限元仿真分析的激励。同时利用应变花进行应力测试,用以验证仿真结果的准确性。改变油压特性曲线的峰值,仿真得到不同的结果。分析仿真结果,冲击状态下应力及振动比静止状态下大很多;减小液压特性曲线的峰值,相应的应力及振动减小。可以得出结论:在施工过程中,液压特性是影响机械臂受力和振动的重要因素。     

Blockage of the NLRP3 inflammasome by MCC950 improves anti-tumor immune responses in head and neck squamous cell carcinoma

The NLRP3 inflammasome is a critical innate immune pathway responsible for producing active interleukin (IL)-1β, which is associated with tumor development and immunity. However, the mechanisms regulating the inflammatory microenvironment, tumorigenesis and tumor immunity are unclear. Herein, we show that the NLRP3 inflammasome was over-expressed in human HNSCC tissues and that the IL-1β concentration was increased in the peripheral blood of HNSCC patients. Additionally, elevated NLRP3 inflammasome levels were detected in tumor tissues of Tgfbr1/Pten 2cKO HNSCC mice, and elevated IL-1β levels were detected in the peripheral blood serum, spleen, draining lymph nodes and tumor tissues. Blocking NLRP3 inflammasome activation using MCC950 remarkably reduced IL-1β production in an HNSCC mouse model and reduced the numbers of myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs) and tumor-associated macrophages (TAMs). Moreover, inhibiting NLRP3 inflammasome activation increased the numbers of CD4⁺ and CD8⁺ T cells in HNSCC mice. Notably, the numbers of exhausted PD-1⁺ and Tim3⁺ T cells were significantly reduced. A human HNSCC tissue microarray showed that NLRP3 inflammasome expression was correlated with the expression of CD8 and CD4, the Treg marker Foxp3, the MDSC markers CD11b and CD33, and the TAM markers CD68 and CD163, PD-1 and Tim3. Overall, our results demonstrate that the NLRP3 inflammasome/IL-1β pathway promotes tumorigenesis in HNSCC and inactivation of this pathway delays tumor growth, accompanied by decreased immunosuppressive cell accumulation and an increased number of effector T cells. Thus, inhibition of the tumor microenvironment through the NLRP3 inflammasome/IL-1β pathway may provide a novel approach for HNSCC therapy.     

高校科技文献管理存在的问题与发展研究

高校院系资料室是图书情报工作不可或缺的组成部分,其发展与完善直接关系着教学、科研信息的来源甚至教学、科研的水平与质量。高校资料室建设中管理松懈脱节、经费缺乏,与图书馆以及各系部资料室之间缺少协调、交流,运作模式传统封闭等问题普遍存在,应加强完善管理格局,提高资金支持制度,加强信息交流,使院系资料室成为具有针对性的专业科技文献信息中心。     

淮海经济区国家高新区发展水平综合评价

构建了由经济规模、经济效益、创新能力3个一级指标以及18个二级指标构成的综合评价指标体系,运用熵值法对淮海经济区的5个国家级高新区的发展水平进行了综合评价.结果发现:5个国家级高新区发展水平存在差距,济宁高新区的发展水平最高,其次是徐州高新区,临沂高新区的发展水平最低.工业经济基础、研发投入、经济规模、结构效益等是影响高新区发展水平差异的主要因素.     

数字量子模拟已经应用到两费米子体系了（英文）

In a recent work,a group of researchers led by Gui-Lu Long of Tsinghua University proposed a digital quantum simulation algorithm for the dynamics of interacting quantum systems in real space.They experimentally implemented the algorithm to simulate the dynamics of two interacting fermions using a nuclear magnetic resonance(NMR)setup[1].